Special Edition Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms with Free EASY Reading Download Now!

Mobi Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms with FREE MOBI EDITION Download Now!

 4,7

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Mobi Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms with FREE MOBI EDITION Download Now!

A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis.In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. Tripping over the Truth follows the story of cancer’s proposed metabolic origin from the vaunted halls of the German scientific golden age to modern laboratories around the world. The reader is taken on a journey through time and science that results in an unlikely connecting of the dots with profound therapeutic implications.Transporting us on a rich narrative of humanity’s struggle to understand the cellular events that conspire to form malignancy, Tripping over the Truth reads like a detective novel, full of twists and cover-ups, blind-alleys and striking moments of discovery by men and women with uncommon vision, grit, and fortitude. Ultimately, Christofferson arrives at a conclusion that challenges everything we thought we knew about the disease, suggesting the reason for the failed war against cancer stems from a flawed paradigm that categorizes cancer as an exclusively genetic disease.For anyone affected by this terrifying disease and the physicians who struggle to treat it, this book provides a fresh and hopeful perspective. It explores the new and exciting non-toxic therapies born from the emerging metabolic theory of cancer. These therapies may one day prove to be a turning point in the struggle against our ancient enemy. We are shown how the metabolic theory redraws the battle map, directing researchers to approach cancer treatment from a different angle, framing it more like a gentle rehabilitation rather than all-out combat. In a sharp departure from the current “targeted” revolution occurring in cancer pharmaceuticals, the metabolic therapies highlighted have one striking feature that sets them apart—the potential to treat all types of cancer because they exploit the one weakness that is common to every cancer cell: dysfunctional metabolism.With a foreword by Dr. Dominic D'Agostino, PhD and contributions from Thomas Seyfried, PhD, author of Cancer as a Metabolic Disease; Miriam Kalamian, EdM, MS, CNS, author of Keto for Cancer; and Beth Zupec Kania, consultant nutritionist of The Charlie Foundation.

At this time of writing, The Ebook Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms has garnered 9 customer reviews with rating of 5 out of 5 stars. Not a bad score at all as if you round it off, it’s actually a perfect TEN already. From the looks of that rating, we can say the Ebook is Good TO READ!

Mobi Tripping over the Truth: How the Metabolic Theory of Cancer Is Overturning One of Medicine's Most Entrenched Paradigms with FREE MOBI EDITION!

The book is well written and certainly brings new life to an old paradigm. However, it is not very balanced.While the Warburg effect is an interesting window into how some tumor cells work, recent studies have shown a "reverse Warburg" effect or “two-compartment tumor metabolism" with several types of tumor, most notably breast and certain brain tumors. In these cases, ketones actually *increase* the size of the tumor and lactate causes it to metastasize (Bonucelli 2010, Martinez 2012). The link between red meat and cancer due to their nitrosamine/nitrile content has also been well established, and not only in colorectal cancer, though certainly unprocessed red meat seems to have less of an impact than processed, and organ meats seem to be beneficial in many ways that muscle meat is not, so this is certainly not clear cut.Tumors with low ketolytic enzyme expression may be unable to metabolize ketone bodies, thus predicting a better response to the ketogenic diet, but cancer is not binary. And it is important to remember that mice are not small furry humans -- their life cycles are much shorter and in experiments their genetics are usually homogenous, unlike in human populations. And forget about cell lines in petri dishes. Even in those scenarios, the results are not clear cut. Cancer cells use many sources of nutrients for fuel, and they change phenotypes often, allowing them to use different fuels as they grow and adapt. There is a mechanism behind this: recent high profile study found that a genetic mutation called BRAF V600E allows cancer cells to use ketones to grow faster. This mutation is present in 50% of melanomas, 10% of colon cancers, 100% of hairy cell leukemias, and 5% of multiple myelomas (Xia et al. 2017). Cancer is smart. Cancer is tough. And cancer did not earn its title as the emperor of all maladies without reason.As with most things in health, human physiology is rarely black and white -- there are countless shades of gray, a whole color spectrum, not to mention UV and infrared variables that we have not discovered yet. While I applaud the book's rebellious spirit and compelling narrative, a lot of folks are grabbing on to this approach desperately looking for a magic bullet.When asked, “Does the ketogenic diet beat chemo for all cancers?” on the Tim Ferris podcast episode #188, Dominic D’Agostino said the following:‘”Absolutely not… A number of situations where the ketogenic diet may not be the preferred therapy for most cancers, I would say, leukemia, lymphomas, Hodgkin’s lymphoma, thyroid cancer, testicular cancer, if caught early prostate cancer, melanoma, breast cancer. All these cancers can be effectively treated with chemotherapy or radiation in some cases, and also brain tumors if it’s grade 1 or 2 tumor that’s not very metastatic and is more localized then surgery, radiation, and chemo can be very effective.”We still do not have a clear answer. Until we do, I would take this text with a tablespoon of salt.References:Bonucelli et al. Ketones and lactate “fuel” tumor growth and metastasis. Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell Cycle. 2010 Sep 1; 9(17): 3506–3514.Martinez-Outschoorn et al. Ketone body utilization drives tumor growth and metastasis. Cell Cycle. 2012 Nov 1; 11(21): 3964–3971Blackburn K. The keto diet and cancer: What patients should know. MD Anderson Cancer Center. Online interview. April 2018.Zhang et al. Low ketolytic enzyme levels in tumors predict ketogenic diet responses in cancer cell lines in vitro and in vivo. Journal of Lipid Research. 2017.Xia et al. Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth. Cell. 2017.

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